In a 100 Gbps fabric configuration, you must install the ES2 10G Uplink line module in slot 2 or slot 4 only.
Conversely, if you install a line module in slot 3 or slot 5 next to a previously installed ES2 10G Uplink module, the non-ES2 10G Uplink module will be disabled. For example, if you install an ES2 10G Uplink line module in both slot 2 and slot 4 in an E320 router, you can install the ES2 4G line module in the following locations: 0-1 and 6-11.